2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 57001-82-8
• Molecular Formula: C₁₈H₁₇Cl₃N₂O₅S
• Molecular Weight: 479.768

Synonyms:2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ⁴-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-bromo-1β-oxo-6β-(2-phenyl-acetylamino)-1λ4-penicillanic acid 2,2,2-trichloro-ethyl ester (57049-10-2) → 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ4-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester (57001-82-8) + (2S)-4-methyl-5t,8-dioxo-7t-(2-phenyl-acetylamino)-(4cH,6cH)-5λ4-thia-1-aza-tricyclo[4.2.0.02,4]octane-2r-carboxylic acid 2,2,2-trichloro-ethyl ester (53030-55-0,57031-05-7)

Guidance literature:

With triethylamine; In acetone;

DOI:10.1021/ja00850a049

Reference yield:

3-methyl-2-[3-oxo-4-(2-phenyl-acetylamino)-3H-isothiazol-2-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester (34094-15-0) → 2-[1,3-dioxo-4-(2-phenyl-acetylamino)-1,3-dihydro-1λ4-isothiazol-2-yl]-3-methyl-but-2-enoic acid 2,2,2-trichloro-ethyl ester (57001-82-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid;

DOI:10.1021/ja00850a049

upstream raw materials:

10-bromo-1β-oxo-6β-(2-phenyl-acetylamino)-1λ⁴-penicillanic acid 2,2,2-trichloro-ethyl ester

3-methyl-2-[3-oxo-4-(2-phenyl-acetylamino)-3H-isothiazol-2-yl]-but-2-enoic acid 2,2,2-trichloro-ethyl ester

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