ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1609250-10-3
Molecular Formula:C₂₃H₂₂O₅
Molecular Weight:378.425
Hs Code.:

Synonyms:ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

There total 3 articles about ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 591-50-4
iodobenzene

: 1465900-92-8
ethyl 5,6-dimethoxy-1-oxo-2-(prop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

: 1609250-10-3
ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: iodobenzene; With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; for 0.5h; Inert atmosphere;

ethyl 5,6-dimethoxy-1-oxo-2-(prop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate; In ethanol; for 2h; Reflux; Inert atmosphere;
DOI:10.1080/00397911.2013.860554

Reference yield:

: 53295-44-6
5,6-(dimethoxy)-2-(ethoxycarbonyl)-indan-1-one

: 1609250-10-3
ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 0.5 h / Inert atmosphere

2.2: 2 h / Reflux; Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; potassium carbonate; triethylamine; triphenylphosphine; In ethanol; acetone;
DOI:10.1080/00397911.2013.860554

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 1609250-10-3
ethyl 5,6-dimethoxy-1-oxo-2-(3-phenylprop-2-ynyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 2 h / 80 °C / Inert atmosphere; Reflux

2.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 0.5 h / Inert atmosphere

3.2: 2 h / Reflux; Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; In ethanol; acetone; mineral oil;
DOI:10.1080/00397911.2013.860554