N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

Base Information

Chemical Name:N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide
CAS No.:1234620-54-2
Molecular Formula:C₂₅H₁₈F₃N₇O
Molecular Weight:489.459
Hs Code.:

Synonyms:N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

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Chemical Property of N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

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Technology Process of N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

There total 5 articles about N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: (rac)-3-amino-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile hydrochloride

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1234620-54-2
N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1234620-54-2
N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentoxide; triethyl phosphate / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

2.1: tert.-butylhydroperoxide / toluene; ethanol / 3 h / 0 - 20 °C

2.2: 15 h

3.1: methanol / 12 h / 20 °C / Inert atmosphere; Molecular sieve

4.1: pyridine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With pyridine; tert.-butylhydroperoxide; triethyl phosphate; phosphorus pentoxide; In tetrahydrofuran; methanol; ethanol; toluene;

Reference yield:

: 1234620-85-9
(rac)-4-(4-Cyanophenyl)-6-methyl-2-thioxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

: 1234620-54-2
N-{6-Cyano-5-(4-cyanophenyl)-7-methyl-8-[3-(trifluoromethyl)phenyl]-5,8-dihydro[1,2,4]triazolo-[4,3-a]pyrimidin-3-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butylhydroperoxide / toluene; ethanol / 3 h / 0 - 20 °C

1.2: 15 h

2.1: methanol / 12 h / 20 °C / Inert atmosphere; Molecular sieve

3.1: pyridine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With pyridine; tert.-butylhydroperoxide; In tetrahydrofuran; methanol; ethanol; toluene;