methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
CAS No.:1445872-73-0
Molecular Formula:C₁₈H₁₂Cl₂F₃NO₃
Molecular Weight:418.199
Hs Code.:

Synonyms:methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

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Technology Process of methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

There total 5 articles about methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1445873-18-6
C₁₈H₁₀Cl₂F₃NO₅

: 1445872-73-0
methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: With triethylsilane; tin(II) chloride dihdyrate; In 1,2-dimethoxyethane; at 20 - 40 ℃; for 3h; Inert atmosphere; Molecular sieve;

Reference yield:

: 259667-65-7
5-iodo-2-methyl-1-nitro-3-(trifluoromethyl)benzene

: 1445872-73-0
methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; triphenylphosphine; sodium carbonate / ethanol; toluene; water / 24.17 h / 20 - 100 °C / Inert atmosphere

2.1: potassium tert-butylate / methanol; diethyl ether / 0.25 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C

3.1: tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

4.1: tin(II) chloride dihdyrate; triethylsilane / 1,2-dimethoxyethane / 3 h / 20 - 40 °C / Inert atmosphere; Molecular sieve

With triethylsilane; tin(II) chloride dihdyrate; potassium tert-butylate; palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; water; toluene;

Reference yield:

: 68716-47-2
2,4-dichlorophenylboronic acid

: 1445872-73-0
methyl 6-(2,4-dichlorophenyl)-1-hydroxy-3-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; triphenylphosphine; sodium carbonate / ethanol; toluene; water / 24.17 h / 20 - 100 °C / Inert atmosphere

2.1: potassium tert-butylate / methanol; diethyl ether / 0.25 h / 0 °C / Inert atmosphere

2.2: 24 h / 0 °C

3.1: tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

4.1: tin(II) chloride dihdyrate; triethylsilane / 1,2-dimethoxyethane / 3 h / 20 - 40 °C / Inert atmosphere; Molecular sieve

With triethylsilane; tin(II) chloride dihdyrate; potassium tert-butylate; palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; water; toluene;