(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

Base Information

Chemical Name:(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid
CAS No.:438629-12-0
Molecular Formula:C₁₆H₂₇N₃O₅S
Molecular Weight:373.473
Hs Code.:

Synonyms:(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

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Technology Process of (3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

There total 3 articles about (3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 438630-55-8
tert-butyl (3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

: 438629-12-0
(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 20h;
DOI:10.1021/jm061010z

Reference yield:

: 944731-37-7
tert-butyl (5Z,9R)-5-amino-9-(3-cyclohexylpropyl)-8-oxo-7-oxa-2-thia-3,6-diazaundec-5-en-11-oate 2,2-dioxide

: 438629-12-0
(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / xylene / 20 h / 130 °C

2: 87 percent / trifluoroacetic acid / toluene / 20 h / 20 °C

With trifluoroacetic acid; In toluene; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 343251-07-0
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

: 438629-12-0
(3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1-carbonyldiimidazole / CH₂Cl₂ / 1.5 h / 20 °C

1.2: 100 percent / CH₂Cl₂; dimethylformamide / 18 h / 20 °C

2.1: 38 percent / xylene / 20 h / 130 °C

3.1: 87 percent / trifluoroacetic acid / toluene / 20 h / 20 °C

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane; toluene; xylene;
DOI:10.1021/jm061010z