Technology Process of 1-(2-cycloheptyl-4-methoxyphenyl)-2-diazoethanone
There total 3 articles about 1-(2-cycloheptyl-4-methoxyphenyl)-2-diazoethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2-cycloheptyl-4-methoxyphenyl)ethanone;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.516667h;
Schlenk technique;
Inert atmosphere;
With
2,2,2-trifluoroethyl trifluoroacetate;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 3h;
Schlenk technique;
Inert atmosphere;
With
4-acetamidobenzenesulfonyl azide; triethylamine;
In
water; acetonitrile;
at 20 ℃;
for 8h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ja403759x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: cobalt(II) bromide; neopentylmagnesium bromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide / tetrahydrofuran / 6 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
1.2: Inert atmosphere; Schlenk technique
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.52 h / -78 °C / Schlenk technique; Inert atmosphere
2.2: 3 h / -78 - 20 °C / Schlenk technique; Inert atmosphere
2.3: 8 h / 20 °C / Schlenk technique; Inert atmosphere
With
neopentylmagnesium bromide; cobalt(II) bromide; lithium hexamethyldisilazane; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide;
In
tetrahydrofuran;
DOI:10.1021/ja403759x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: cobalt(II) bromide; neopentylmagnesium bromide; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide / tetrahydrofuran / 6 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
1.2: Inert atmosphere; Schlenk technique
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.52 h / -78 °C / Schlenk technique; Inert atmosphere
2.2: 3 h / -78 - 20 °C / Schlenk technique; Inert atmosphere
2.3: 8 h / 20 °C / Schlenk technique; Inert atmosphere
With
neopentylmagnesium bromide; cobalt(II) bromide; lithium hexamethyldisilazane; 1,3-diisopropyl-1H-benzo[d]imidazol-3-ium bromide;
In
tetrahydrofuran;
DOI:10.1021/ja403759x
