5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

Base Information

Chemical Name:5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid
CAS No.:1333921-59-7
Molecular Formula:C₂₈H₁₉ClN₂O₅
Molecular Weight:498.922
Hs Code.:

Synonyms:5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

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Chemical Property of 5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

Chemical Property:

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Technology Process of 5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

There total 8 articles about 5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1333921-58-6
5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-(dichloromethyl)benzoyl)benzoic acid

: 1333921-59-7
5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

Guidance literature:: 5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-(dichloromethyl)benzoyl)benzoic acid; With water; N,N-dimethylammonium chloride; sodium hydroxide; In ethanol; at 60 ℃; for 50h;

With hydrogenchloride; In ethanol; water; at 20 ℃; pH=~ 5;

Reference yield:

: 932-96-7
N-methyl(p-chloroaniline)

: 1333921-59-7
5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 15 h / 85 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / -15 °C

2.2: 16 h / -45 - 20 °C

2.3: 0.5 h / 0 - 20 °C

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 1.5 h / 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 5 h / 105 °C

5.1: bis(η3-allyl-μ-chloropalladium(II)) / toluene / 4.5 h / 44 °C

6.1: sodium hydroxide; water / ethanol / 0.08 h / 65 °C

6.2: pH ~ 5

7.1: N,N-dimethylammonium chloride; sodium hydroxide; water / ethanol / 50 h / 60 °C

7.2: 20 °C / pH ~ 5

With water; isopropylmagnesium chloride; N,N-dimethylammonium chloride; caesium carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;

Reference yield:

: 1244043-46-6
5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbaldehyde

: 1333921-59-7
5-(5-((4-chlorophenyl)(methyl)amino)picolinoyl)-2-(3-formylbenzoyl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -15 °C

1.2: 16 h / -45 - 20 °C

1.3: 0.5 h / 0 - 20 °C

2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 1.5 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 5 h / 105 °C

4.1: bis(η3-allyl-μ-chloropalladium(II)) / toluene / 4.5 h / 44 °C

5.1: sodium hydroxide; water / ethanol / 0.08 h / 65 °C

5.2: pH ~ 5

6.1: N,N-dimethylammonium chloride; sodium hydroxide; water / ethanol / 50 h / 60 °C

6.2: 20 °C / pH ~ 5

With water; isopropylmagnesium chloride; N,N-dimethylammonium chloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;