16-Hydroxy-strychnine

Base Information

• Chemical Name: 16-Hydroxy-strychnine
• CAS No.: 465-62-3
• Molecular Formula: C21H22N2O3
• Molecular Weight: 350.411
• Mol file: 465-62-3.mol

Synonyms:psi-Strychnine;16-Hydroxy-strychnine;Strychnidin-10-one, 16-hydroxy-;NSC 99792

Chemical Property of 16-Hydroxy-strychnine

Chemical Property:

• Vapor Pressure: 1.15E-15mmHg at 25°C
• Boiling Point: 608.6°C at 760 mmHg
• Flash Point: 321.9°C
• Density: 1.5g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 350.16304257
• Heavy Atom Count: 26
• Complexity: 722

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C=C2CN3CC(C45C3CC2C6C4N(C(=O)CC6O1)C7=CC=CC=C57)O
• Isomeric SMILES: C1C=C2CN3C[C@H](C45C3C[C@@H]2[C@@H]6[C@@H]4N(C(=O)C[C@@H]6O1)C7=CC=CC=C57)O

Technology Process of 16-Hydroxy-strychnine

There total 6 articles about 16-Hydroxy-strychnine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

strychnine-N-oxide (7248-28-4) → 18-Hydroxystrychnin + (-)-pseudostrychnine (465-62-3)

Guidance literature:

strychnine-N-oxide; With trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 5h;

With potassium hydroxide; In dichloromethane; water; at 20 ℃; for 20h; Reagent/catalyst; Temperature;

DOI:10.1002/chem.201602663

Reference yield: 17.0%

strychnine-N-oxide (7248-28-4) → 18-Oxostrychnin (27239-48-1) + (-)-pseudostrychnine (465-62-3)

Guidance literature:

With potassium dichromate; In 1,4-dioxane; water; for 1.25h; Heating;

DOI:10.1002/jlac.198019800610

Reference yield:

strychnine-N-oxide (7248-28-4) → (-)-pseudostrychnine (465-62-3)

Guidance literature:

strychnine-N-oxide; With trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate;

DOI:10.21577/0103-5053.20180217

upstream raw materials:

strychnidin-10-one

strychnine-N-oxide

Downstream raw materials:

strychnicine

icajine

Refernces

• 1、 Phillipson,Bisset. "". . p. 2547,2552. Retrieved 1972.
• 2、 Rosenmund,Schmitt,Franke. "Vomicine from strychnine". . p. 895 - 907. Retrieved 2007/10/02.