N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid

Base Information

• Chemical Name: N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid
• CAS No.: 77773-78-5
• Molecular Formula: C₁₂H₁₆N₄O₄
• Molecular Weight: 280.283
• Mol file: 77773-78-5.mol

Synonyms:N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid

Chemical Property of N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid

There total 1 articles about N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-[(3-Azido-2,2-dimethoxy-propyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid ethyl ester (77773-77-4) → N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid (77773-78-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 18h;

DOI:10.1021/jo00328a042

Reference yield:

N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid (77773-78-5) → N-(1-Amino-2,2-dimethoxypropyl)-p-aminobenzoic acid (77773-79-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 18h; under 1292.9 Torr;

DOI:10.1021/jo00328a042

Reference yield:

N-(1-Azido-2,2-dimethoxypropyl)-p-aminobenzoic acid (77773-78-5) → 4-amino>benzoic acid (36093-85-3)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 5percent palladium on carbon / methanol / 18 h / 1292.9 Torr

2: 80 percent / methanol / 4 h / Heating

3: 86 percent / 0.1 N HCl / trifluoroacetic acid / 55 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; trifluoroacetic acid;

DOI:10.1021/jo00328a042

upstream raw materials:

4-[(3-Azido-2,2-dimethoxy-propyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoic acid ethyl ester

Downstream raw materials:

N-(1-Amino-2,2-dimethoxypropyl)-p-aminobenzoic acid

7,8-Dihydropteroic acid

4-amino>benzoic acid

4-[3-(2,6-Diamino-5-nitro-pyrimidin-4-ylamino)-2-oxo-propylamino]-benzoic acid

Refernces