methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

Base Information

Chemical Name:methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate
CAS No.:637348-20-0
Molecular Formula:C₁₈H₁₇NO₄
Molecular Weight:311.337
Hs Code.:

Synonyms:methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

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Chemical Property of methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

Chemical Property:

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Technology Process of methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

There total 4 articles about methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 615-43-0
2-iodophenylamine

: 637348-14-2
2-ethynyl-4,5-dimethoxy-benzoic acid methyl ester

: 637348-20-0
methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

Guidance literature:: With copper(l) iodide; diethylamine; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1055/s-2003-40984

Reference yield:

: 173043-61-3
2-iodo-4,5-dimethoxybenzoic acid methyl ester

: 637348-20-0
methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₂NH; CuI / PdCl₂(PPh₃)2 / tetrahydrofuran / 1.5 h / 20 °C

2: TBAF / CH₂Cl₂ / 0.33 h / 20 °C

3: 90 percent / Et₂NH; CuI / PdCl₂(PPh₃)3 / tetrahydrofuran / 12 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; bis-triphenylphosphine-palladium(II) chloride; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1055/s-2003-40984

Reference yield:

: 4,5-dimethoxy-2-trimethylsilanylethynyl-benzoic acid methyl ester

: 637348-20-0
methyl 2-((2-aminophenyl)ethynyl)-4,5-dimethoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: TBAF / CH₂Cl₂ / 0.33 h / 20 °C

2: 90 percent / Et₂NH; CuI / PdCl₂(PPh₃)3 / tetrahydrofuran / 12 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; bis(triphenylphosphine)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;
DOI:10.1055/s-2003-40984