(+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

Base Information

• Chemical Name: (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid
• CAS No.: 87866-94-2
• Molecular Formula: C₂₆H₄₁N₅O₆
• Molecular Weight: 519.641
• Mol file: 87866-94-2.mol

Synonyms:(+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

Chemical Property of (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid

There total 7 articles about (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(+/-)-2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure (112142-64-0) + 3-dimethylamino-2,2-dimethyl-2H-azirine (54856-83-6) → (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid (87866-94-2)

Guidance literature:

In N,N-dimethyl-formamide; acetonitrile; Ambient temperature;

DOI:10.1002/hlca.19870700209

Reference yield:

(+/-)-2-(2-hydroxy-2-phenylacetamido)-N,N,2-trimethylpropionamid (111492-13-8) → (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid (87866-94-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 96 percent / HCl / acetonitrile; H₂O / 0.17 h / 60 - 70 °C

2: 93 percent / acetonitrile / 2 h / Ambient temperature

3: 85 percent / HCl / toluene / 0.08 h / 100 °C

4: acetonitrile; H₂O / Ambient temperature

5: 91 percent / acetonitrile / 2 h / Ambient temperature

6: 94 percent / HCl / acetonitrile; H₂O / 60 - 70 °C

7: 88 percent / acetonitrile; dimethylformamide / Ambient temperature

With hydrogenchloride; In water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1002/hlca.19870700209

Reference yield:

(+/-)-2-(2-hydroxy-2-phenylacetamido)-2-methylpropionsaure (111492-26-3) → (+/-)-2-<2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionamido>-N,N,2-trimethylpropionamid (87866-94-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 93 percent / acetonitrile / 2 h / Ambient temperature

2: 85 percent / HCl / toluene / 0.08 h / 100 °C

3: acetonitrile; H₂O / Ambient temperature

4: 91 percent / acetonitrile / 2 h / Ambient temperature

5: 94 percent / HCl / acetonitrile; H₂O / 60 - 70 °C

6: 88 percent / acetonitrile; dimethylformamide / Ambient temperature

With hydrogenchloride; In water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1002/hlca.19870700209

upstream raw materials:

(+/-)-2-<2-<2-(2-hydroxy-2-phenylacetamido)-2-methylpropionamido>-2-methylpropionamido>-2-methylpropionsaeure

3-dimethylamino-2,2-dimethyl-2H-azirine

(+/-)-2-(2-hydroxy-2-phenylacetamido)-2-methylpropionsaure

(+/-)-2-(2-hydroxy-2-phenylacetamido)-N,N,2-trimethylpropionamid

Downstream raw materials:

3,3,6,6,9,9,12,12-octamethyl-15-phenyl-1-oxa-4,7,10,13-tetraazacyclopentadecan-2,5,8,11,14-penton