N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

Base Information

Chemical Name:N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide
CAS No.:228726-66-7
Molecular Formula:C₁₈H₁₄ClFN₂O₃
Molecular Weight:360.772
Hs Code.:

Synonyms:N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

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Technology Process of N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

There total 2 articles about N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1224582-34-6
C₂₄H₁₆ClFN₂O₃S

: 228726-66-7
N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2010.01.094

Reference yield:

: 228726-66-7
N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

Guidance literature:

Reference yield: 89.0%

: 228726-66-7
N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(hydroxymethyl)-3-quinolinecarboxamide

: N-(4-chlorobenzyl)-6-(chloromethyl)-8-fluoro-4-hydroxy-3-quinolinecarboxamide

Guidance literature:: With 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.01.094