(R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate

Base Information

• Chemical Name: (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate
• CAS No.: 1620084-96-9
• Molecular Formula: C₃₀H₄₀N₂O₃
• Molecular Weight: 476.659
• Mol file: 1620084-96-9.mol

Synonyms:(R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate

Chemical Property of (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate

There total 2 articles about (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

γ-aminobutyric acid methyl ester hydrochloride salt + (R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid (1620084-99-2) → (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate (1620084-96-9)

Guidance literature:

With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid (80789-69-1) → (R)-methyl 4-(1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxamido)butanoate (1620084-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 0.17 h / 150 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate; triethylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

upstream raw materials:

(R)-1-(4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)cyclopentanecarboxylic acid

1-(4-chlorophenyl)cyclopentane-1-carboxylic acid