(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester
CAS No.:451498-74-1
Molecular Formula:C₂₁H₂₈N₂O₂
Molecular Weight:340.466
Hs Code.:

Synonyms:(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

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Chemical Property of (1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

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Technology Process of (1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

There total 4 articles about (1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 451498-72-9
(+)-(1S,2R)-methyl 2-{N-[(1R)-2-(indol-3-yl)-1-methylethyl]acetamido}cyclohexane-1-carboxylate

: 451498-74-1
(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: (+)-(1S,2R)-methyl 2-{N-[(1R)-2-(indol-3-yl)-1-methylethyl]acetamido}cyclohexane-1-carboxylate; With trichlorophosphate; In toluene; for 3h; Heating;

With sodium tetrahydroborate; In methanol; water;
DOI:10.1002/1522-2675(200203)85:3<945::AID-HLCA945>3.0.CO;2-A

Reference yield:

: 7795-52-0,304-54-1
(-)-alpha-Methyltryptamine

: 451498-74-1
(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 73 percent / 2-chloro-1-methylpyridinium iodide; Bu₃N / CH₂Cl₂ / 2 h / Heating

2.1: POCl₃ / toluene / 3 h / Heating

2.2: 70 percent / NaBH₄ / methanol; H₂O

With tributyl-amine; 2-chloro-1-methyl-pyridinium iodide; trichlorophosphate; In dichloromethane; toluene;
DOI:10.1002/1522-2675(200203)85:3<945::AID-HLCA945>3.0.CO;2-A

Reference yield:

: 200948-89-6
(1S,2S)-cyclohexane 1,2-dicarboxylic acid mono-methyl ester

: 451498-74-1
(1S,2R)-2-((1S,3R)-3-Methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride / 0.67 h / 25 °C

1.2: diethyl ether

1.3: Ag₂O / H₂O; dioxane

2.1: 73 percent / 2-chloro-1-methylpyridinium iodide; Bu₃N / CH₂Cl₂ / 2 h / Heating

3.1: POCl₃ / toluene / 3 h / Heating

3.2: 70 percent / NaBH₄ / methanol; H₂O

With oxalyl dichloride; tributyl-amine; 2-chloro-1-methyl-pyridinium iodide; trichlorophosphate; In dichloromethane; toluene;
DOI:10.1002/1522-2675(200203)85:3<945::AID-HLCA945>3.0.CO;2-A