(S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone

Base Information

• Chemical Name: (S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone
• CAS No.: 936347-55-6
• Molecular Formula: C₂₀H₂₄N₂O₂
• Molecular Weight: 324.423
• Mol file: 936347-55-6.mol

Synonyms:(S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone

Chemical Property of (S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone

There total 1 articles about (S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

pyridine-3-carbonyl chloride hydrochloride (20260-53-1) + (4S)-2,2,5,5-tetramethyl-4-phenylmethyloxazolidine (144899-42-3) → (S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone (936347-55-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1021/ol070168q

Reference yield:

(S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone (936347-55-6) + methyl chloroformate (79-22-1) + prenyl bromide (870-63-3) → (4R)-3-((4S)-4-benzyl-2,2,5,5-tetramethyl-oxazolidine-3-carbonyl)-4-prenyl-4H-pyridine-1-carboxylic acid methyl ester + (4S,4'S)-3-(4-benzyl-2,2,5,5-tetramethyl-oxazolidine-3-carbonyl)-4-prenyl-4H-pyridine-1-carboxylic acid methyl ester + (4S,2'S)-5-(4-benzyl-2,2,5,5-tetramethyl-oxazolidine-3-carbonyl)-2-prenyl-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:

(S)-(4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)pyridin-3-yl-methanone; prenyl bromide; With indium; In tetrahydrofuran; at 20 ℃; for 1h;

methyl chloroformate; In tetrahydrofuran; at 0 ℃; Further stages.;

DOI:10.1021/ol070168q

upstream raw materials:

pyridine-3-carbonyl chloride hydrochloride

(4S)-2,2,5,5-tetramethyl-4-phenylmethyloxazolidine