N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Base Information

Chemical Name:N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester
CAS No.:218915-08-3
Molecular Formula:C₄₇H₆₇ClN₄O₁₁Si
Molecular Weight:927.608
Hs Code.:

<i>N</i>-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(<i>tert</i>-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Synonyms:N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

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Chemical Property of N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

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Technology Process of N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

There total 18 articles about N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 218915-07-2
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

: 218915-08-3
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: With sulfuryl dichloride; In diethyl ether; at 25 ℃;
DOI:10.1002/(SICI)1521-3773(19981016)37:19<2714::AID-ANIE2714>3.0.CO;2-#

Reference yield:

: 218915-02-7
Asn(Mbh)-OMe

: 218915-08-3
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / HOAt; EDC / tetrahydrofuran / 0 - 25 °C

2: 81 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

3: 99 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 1 h / 25 °C

4: 75 percent / SO₂Cl₂ / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; sulfuryl dichloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Acylation / 2: Etherification / 3: Hydrogenolysis / 4: Chlorination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X

Reference yield:

: 28252-50-8
N^α-Cbz-N^γ-(4,4'-dimethoxybenzhydryl)-Asn-OH

: 218915-08-3
N-[bis-(4-methoxy-phenyl)-methyl]-2-[2-[2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionylamino]-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / K₂CO₃ / dimethylformamide / 12 h / 25 °C

2: 99 percent / H₂ / 20 percent Pd(OH)2 / methanol / 1 h / 25 °C

3: 82 percent / HOAt; EDC / tetrahydrofuran / 0 - 25 °C

4: 81 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

5: 99 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 1 h / 25 °C

6: 75 percent / SO₂Cl₂ / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; sulfuryl dichloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrogenolysis / 3: Acylation / 4: Etherification / 5: Hydrogenolysis / 6: Chlorination;
DOI:10.1002/(SICI)1521-3765(19990903)5:9<2602::AID-CHEM2602>3.0.CO;2-X