methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate

Base Information

• Chemical Name: methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate
• CAS No.: 740075-69-8
• Molecular Formula: C₂₁H₂₄N₄O₄S
• Molecular Weight: 428.512
• Mol file: 740075-69-8.mol

Synonyms:methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate

Chemical Property of methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate

There total 4 articles about methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(tert-butoxycarbonylamino-methyl)-benzoic acid 2-methoxycarbonylamino-5-propylsulfanyl-benzoimidazol-1-ylmethyl ester → methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate (740075-69-8)

Guidance literature:

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 3h;

DOI:10.1016/S0960-894X(01)00214-1

Reference yield:

p-aminomethylbenzoic acid (56-91-7) → methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate (740075-69-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 2-methyl-propan-2-ol

2.1: aq. NaHCO₃; [Ch₃(CH₂)3]4N(HSO₄) / CH₂Cl₂

3.1: NaH / dimethylformamide / 2 h

3.2: dimethylformamide / 12 h

4.1: HCl / ethyl acetate; ethanol / 3 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; sodium hydrogencarbonate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0960-894X(01)00214-1

Reference yield:

4-(tert-Butoxycarbonylaminomethyl)benzoic acid (33233-67-9) → methyl 1-[(4-aminomethyl)benzoyloxy]-5-(propylthio)-2-benzimidazole-carbamate (740075-69-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. NaHCO₃; [Ch₃(CH₂)3]4N(HSO₄) / CH₂Cl₂

2.1: NaH / dimethylformamide / 2 h

2.2: dimethylformamide / 12 h

3.1: HCl / ethyl acetate; ethanol / 3 h / 20 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; sodium hydrogencarbonate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00214-1

upstream raw materials:

p-aminomethylbenzoic acid

4-(tert-Butoxycarbonylaminomethyl)benzoic acid

chloromethyl 4-(((tert-butoxycarbonyl)amino)methyl)benzoate

Downstream raw materials:

Albendazole