N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide

Base Information

• Chemical Name: N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide
• CAS No.: 1253113-34-6
• Molecular Formula: C₁₇H₁₃F₂N₃O₂
• Molecular Weight: 329.306

Synonyms:N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide

Chemical Property of N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide

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Technology Process of N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide

There total 1 articles about N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,6-difluorophenyl)-1-((2-[(phenylmethyl)oxy]phenyl)methyl)-1H-pyrazole-3-carboxamide (1253112-83-2) → N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide (1253113-34-6)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

3,5-di-tert-butylbenzyl bromide (62938-08-3) + N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide (1253113-34-6) → 1-{[2-({[3,5-bis(1,1-dimethylethyl)phenyl]methyl}oxy)phenyl]methyl}-N-(2,6-difluorophenyl)-1H-pyrazole-3-carboxamide (1253113-18-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

1-bromo-2-methyl-butane (10422-35-2,99032-67-4,534-00-9,5973-11-5) + N-(2,6-difluorophenyl)-1-[(2-hydroxyphenyl)methyl]-1H-pyrazole-3-carboxamide (1253113-34-6) → N-(2,6-difluorophenyl)-1-((2-[(2-methylbutyl)oxy]phenyl)methyl)-1H-pyrazole-3-carboxamide (1253112-87-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

upstream raw materials:

N-(2,6-difluorophenyl)-1-((2-[(phenylmethyl)oxy]phenyl)methyl)-1H-pyrazole-3-carboxamide

Downstream raw materials:

N-(2,6-difluorophenyl)-1-[(2-{[(4-methylphenyl)methyl]oxy}phenyl)methyl]-1H-pyrazole-3-carboxamide

N-(2,6-difluorophenyl)-1-{[2-({[2-(ethyloxy)phenyl]methyl}oxy)phenyl]methyl}-1H-pyrazole-3-carboxamide

N-(2,6-difluorophenyl)-1-((2-[(3-methyl-2-buten-1-yl)oxy]phenyl)methyl)-1H-pyrazole-3-carboxamide

N-(2,6-difluorophenyl)-1-((2-[(2-methylpropyl)oxy]phenyl)methyl)-1H-pyrazole-3-carboxamide

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