1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:200562-19-2
Molecular Formula:C₃₈H₃₇N₃O₁₁
Molecular Weight:711.725
Hs Code.:

1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Synonyms:1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 3 articles about 1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,4R,5S)-5-Triisopropylsilanyloxymethyl-tetrahydro-furan-2,3,4-triol

: 200562-19-2
1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂; pyridine / 14 h / Ambient temperature

2: 1.) BSA, SnCl₄; 2.) conc. aq. HCl / 1.) MeCN, 60 deg C, 1 h; 2.) THF, r.t., 1 h

3: 1.) (i-Pr)2NEt; 2.) 10N aq. NaOH / 1.) CH₂Cl₂, r.t., 30 min; 2.) CH₂Cl₂, THF, MeOH, 4 deg C, 25 min

4: 1.) (i-Pr)2NEt, Bu₂SnCl₂ / 1.) CH₂Cl₂, r.t., 90 min; 2.) CH₂Cl₂, 80 deg C, 20 min

With hydrogenchloride; benzenesulfonamide; sodium hydroxide; dibutyltin chloride; tin(IV) chloride; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1002/hlca.19970800803

Reference yield:

: 200562-09-0
1-(2',3'-di-O-benzoyl-β-L-ribofuranosyl)uracil

: 200562-19-2
1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (i-Pr)2NEt; 2.) 10N aq. NaOH / 1.) CH₂Cl₂, r.t., 30 min; 2.) CH₂Cl₂, THF, MeOH, 4 deg C, 25 min

2: 1.) (i-Pr)2NEt, Bu₂SnCl₂ / 1.) CH₂Cl₂, r.t., 90 min; 2.) CH₂Cl₂, 80 deg C, 20 min

With sodium hydroxide; dibutyltin chloride; N-ethyl-N,N-diisopropylamine;
DOI:10.1002/hlca.19970800803

Reference yield:

: 149622-93-5
<(2-Nitrobenzyl)oxy>methyl chloride

: 144385-60-4
5'-O-(4,4'-dimethoxytrityl)-L-uridine

: 200562-27-2
1-[(2S,3S,4R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 200562-19-2
1-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With dibutyltin chloride; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, r.t., 90 min; 2.) CH₂Cl₂, 80 deg C, 20 min;
DOI:10.1002/hlca.19970800803