3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Chemical Name:3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one
CAS No.:1613395-06-4
Molecular Formula:C₂₂H₁₆ClF₄N₅O₂
Molecular Weight:493.848
Hs Code.:

Synonyms:3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Chemical Property of 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

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Technology Process of 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

There total 8 articles about 3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₂ClF₄N₅O₅S

: 1613395-06-4
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 138907-70-7
ethyl 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1613395-06-4
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 20 - 50 °C

2: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran

3: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; 1,4-dioxane; water / 100 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2 h / 20 °C

7: triethylamine / dichloromethane / 0.5 h / 20 °C

8: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; diiodomethane; diphenyl phosphoryl azide; water; trimethylaluminum; sodium hydride; potassium carbonate; triethylamine; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile; mineral oil; 4: |Suzuki Coupling;

Reference yield:

: 1613395-67-7
ethyl 5-iodo-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1613395-06-4
3-[4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-[1-(3-fluorophenyl)-5-(furan-3-yl)-1H-pyrazol-4-yl]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hydroxide monohydrate; water / methanol; tetrahydrofuran

2: triethylamine; diphenyl phosphoryl azide / 20 - 60 °C / Molecular sieve

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; 1,4-dioxane; water / 100 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

5: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2 h / 20 °C

6: triethylamine / dichloromethane / 0.5 h / 20 °C

7: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; trimethylaluminum; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; mineral oil; 3: |Suzuki Coupling;