N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

Base Information

Chemical Name:N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide
CAS No.:224946-94-5
Molecular Formula:C₁₆H₁₇N₅O
Molecular Weight:295.344
Hs Code.:

Synonyms:N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

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Chemical Property of N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

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Technology Process of N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

There total 5 articles about N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4214-85-1
2-amino-6-methyl-5-nitro-4(3H)-oxopyrimidine

: 224946-94-5
N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / CH₂Cl₂ / 1 h / 20 °C

2: 31.5 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

3: dimethylformamide / 65 °C

4: 29.5 g / Na₂S₂O₄ / tetrahydrofuran; H₂O / 1 h

With sodium dithionite; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Condensation / 2: Alkylation / 3: Condensation / 4: Cyclization;
DOI:10.1080/15257779908043082

Reference yield:

: 3977-29-5
2-amino-6-methyl-3H-pyrimidin-4-one

: 224946-94-5
N′-(3-benzyl-4-oxo-4,5-dihydro-3H-pyrrolo-[3,2-d]pyrimidin-2-yl)-N,N-dimethylformimidamide

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / nitric acid / H₂SO₄ / 1 h / 50 °C

2: 92 percent / CH₂Cl₂ / 1 h / 20 °C

3: 31.5 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

4: dimethylformamide / 65 °C

5: 29.5 g / Na₂S₂O₄ / tetrahydrofuran; H₂O / 1 h

With sodium dithionite; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; sulfuric acid; water; N,N-dimethyl-formamide; 1: Nitration / 2: Condensation / 3: Alkylation / 4: Condensation / 5: Cyclization;
DOI:10.1080/15257779908043082