N-methyl-3,4-methylenedioxybenzanilide

Base Information

• Chemical Name: N-methyl-3,4-methylenedioxybenzanilide
• CAS No.: 81568-79-8
• Molecular Formula: C₁₅H₁₃NO₃
• Molecular Weight: 255.273
• Mol file: 81568-79-8.mol

Synonyms:N-methyl-3,4-methylenedioxybenzanilide

Chemical Property of N-methyl-3,4-methylenedioxybenzanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-3,4-methylenedioxybenzanilide

There total 2 articles about N-methyl-3,4-methylenedioxybenzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-(methylenedioxy)benzoyl chloride (25054-53-9) + N-methylaniline (100-61-8) → N-methyl-3,4-methylenedioxybenzanilide (81568-79-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/acs.joc.1c00931

Reference yield: 54.0%

2-bromo-N-methyl-4,5-methylenedioxybenzanilide (40141-79-5) → N-methylcrinasiadine (40141-98-8) + N-methyl-4,5-methylenedioxybiphenyl-2-carboxamide (81568-78-7) + N-methyl-3,4-methylenedioxybenzanilide (81568-79-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; for 24h; electrochemical reduction;

Reference yield: 44.0%

N-methyl-3,4-methylenedioxybenzanilide (81568-79-8) + N,N-tert-butoxycarbonyldehydroalanine (201338-62-7) → C29H38N2O8

Guidance literature:

N-methyl-3,4-methylenedioxybenzanilide; With bis(triphenylphosphine)iridium(I) carbonyl chloride; 1,1,3,3-Tetramethyldisiloxane; In toluene; at 20 ℃; for 1h; Inert atmosphere;

N,N-tert-butoxycarbonyldehydroalanine; With Ir(dF(CF₃)ppy)2(bpy)PF₆; diethyl 4-[4-(methoxycarbonyl)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; dimethyl sulfoxide; In toluene; at 30 ℃; for 16h; Inert atmosphere; Irradiation;

DOI:10.1021/acscatal.0c03089

upstream raw materials:

2-bromo-N-methyl-4,5-methylenedioxybenzanilide

3,4-(methylenedioxy)benzoyl chloride

N-methylaniline