3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

Base Information

Chemical Name:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile
CAS No.:1384083-05-9
Molecular Formula:C₂₅H₂₅BrN₄O
Molecular Weight:477.404
Hs Code.:

Synonyms:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

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Chemical Property of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

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Technology Process of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

There total 8 articles about 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383983-77-4
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

: 1384083-05-9
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

: 1383983-78-5
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

Guidance literature:: With diethylamine; In methanol; carbon dioxide;

Reference yield:

: 1245515-16-5
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-1'(3'H)-one

: 1384083-05-9
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

: 1383983-78-5
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 26 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: methanol / 15 h / 60 °C / Inert atmosphere

4: ammonia / methanol / 74 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 110 °C / Microwave irradiation; Sealed vessel

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation; Sealed vessel

7: diethylamine / carbon dioxide; methanol

With hydrogenchloride; titanium(IV) tetraethanolate; ammonia; potassium acetate; potassium carbonate; diethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; water;

Reference yield:

: 1383985-57-6
N-(5'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-3'(1'H)-ylidene)-2-methylpropane-2-sulfinamide

: 1384083-05-9
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

: 1383983-78-5
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-bromobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

2: methanol / 15 h / 60 °C / Inert atmosphere

3: ammonia / methanol / 74 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 110 °C / Microwave irradiation; Sealed vessel

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation; Sealed vessel

6: diethylamine / carbon dioxide; methanol

With hydrogenchloride; ammonia; potassium acetate; potassium carbonate; diethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; carbon dioxide; water;