methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate

Base Information

• Chemical Name: methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate
• CAS No.: 225942-83-6
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.353
• Mol file: 225942-83-6.mol

Synonyms:methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate

Chemical Property of methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate

There total 1 articles about methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

3-hydroxy-N,N-dimethylbenzamide (15789-03-4) + 3-methoxycarbonylbenzyl bromide (1129-28-8) → methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate (225942-83-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1248/cpb.47.481

Reference yield: 79.2%

methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate (225942-83-6) → 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoic acid (225942-84-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

DOI:10.1248/cpb.47.481

Reference yield:

methyl 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoate (225942-83-6) → 3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoic acid chloride

Guidance literature:

Multi-step reaction with 2 steps

1: 79.2 percent / 1 N aq. NaOH / tetrahydrofuran; methanol / 4 h / 20 °C

2: (COCl)2, DMF / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1248/cpb.47.481

upstream raw materials:

3-hydroxy-N,N-dimethylbenzamide

3-methoxycarbonylbenzyl bromide

Downstream raw materials:

3-<3-(N,N-dimethylaminocarbonyl)phenoxymethyl>benzoic acid