(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

Base Information

Chemical Name:(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene
CAS No.:118892-18-5
Molecular Formula:C₂₁H₂₅NO₃S
Molecular Weight:371.5
Hs Code.:

Synonyms:(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

Chemical Property:

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Technology Process of (1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

There total 4 articles about (1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56069-39-7
diethyl phenylsulfonylmethylphosphonate

: 103498-90-4,118892-13-0,118892-30-1
(2SR,4RS)-2-(2-formyl-2-propenyl)-4-methyl-6-oxocyclohexanepropanenitrile

: 118892-18-5
(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 2 h, 2.) RT, overnight;
DOI:10.1021/jo00268a015

Reference yield:

: 69060-78-2
2-(2-cyanoethyl)-5-methylcyclohex-2-en-1-one

: 118892-18-5
(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) TiCl₄ / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) from -70 to -78 deg C, 4 h

2: 94 percent / chromic anhydride, pyridine / CH₂Cl₂ / 0.5 h

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) RT, overnight

With pyridine; chromium(VI) oxide; n-butyllithium; titanium tetrachloride; In dichloromethane;
DOI:10.1021/jo00268a015

Reference yield:

: 42747-36-4
2-chloro-4-methyl-6-oxo-1-cyclohexene-1-propanenitrile

: 118892-18-5
(1SR,3aSR,5RS,7aSR)-7a-(2-cyanoethyl)octahydro-5-methyl-2-methylene-7-oxo-1-<(phenylsulfonyl)methyl>-1H-indene

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / zinc-silver couple / methanol / 2 h

2: 1.) TiCl₄ / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) from -70 to -78 deg C, 4 h

3: 94 percent / chromic anhydride, pyridine / CH₂Cl₂ / 0.5 h

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) RT, overnight

With pyridine; chromium(VI) oxide; n-butyllithium; zinc silver; titanium tetrachloride; In methanol; dichloromethane;
DOI:10.1021/jo00268a015