(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

Base Information

Chemical Name:(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane
CAS No.:228573-43-1
Molecular Formula:C₁₉H₂₃NO₂
Molecular Weight:297.397
Hs Code.:

Synonyms:(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

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Chemical Property of (+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

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Technology Process of (+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

There total 3 articles about (+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 106-96-7
propargyl bromide

: 348135-74-0
(+/-)-1-benzyloxycarbonylamino-1-methyl-2-methylenecyclohexane

: 228573-43-1
(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(01)00151-X

Reference yield:

: 49716-75-8
1-methyl-2-methyliden-1-cyclohexancarbonsaeure

: 228573-43-1
(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / DPPA; Et₃N / toluene / 6 h / Heating

2: 54 percent / NaH / dimethylformamide / 3 h / 20 °C

With diphenyl-phosphinic acid; sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)00151-X

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 228573-43-1
(+/-)-1-(N-benzyloxycarbonylpropargylamino)-1-methyl-2-methylenecyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / DPPA; Et₃N / toluene / 6 h / Heating

2: 54 percent / NaH / dimethylformamide / 3 h / 20 °C

With diphenyl-phosphinic acid; sodium hydride; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)00151-X