dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

Base Information

Chemical Name:dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate
CAS No.:1470004-77-3
Molecular Formula:C₂₂H₂₂O₅
Molecular Weight:366.414
Hs Code.:

Synonyms:dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

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Chemical Property of dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

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Technology Process of dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

There total 8 articles about dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 591-50-4
iodobenzene

: dimethyl 2-(buta-2,3-dien-1-yl)-2-(4-hydroxybenzyl)malonate

: 1470004-77-3
dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

: C₄₄H₄₄O₁₀

Guidance literature:: With potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Solvent; Temperature; Concentration; Inert atmosphere;
DOI:10.1002/adsc.201300326

Reference yield:

: 591-50-4
iodobenzene

: dimethyl 2-(buta-2,3-dien-1-yl)-2-(4-hydroxybenzyl)malonate

: 1470004-77-3
dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

Guidance literature:: With C₃₄H₂₆O; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 18h; Reagent/catalyst; Inert atmosphere;
DOI:10.1002/adsc.201300326

Reference yield:

: 100747-44-2
dimethyl 2,3-butadienylmalonate

: 1470004-77-3
dimethyl 8-oxo-4-(1-phenylvinyl)spiro[4.5]deca-6,9-diene-2,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium carbonate; C₃₄H₂₆O / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

With C₃₄H₂₆O; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; acetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/adsc.201300326