(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

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Chemical Name:(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea
CAS No.:1285500-15-3
Molecular Formula:C₂₂H₂₉N₇O₂
Molecular Weight:423.518
Hs Code.:

Synonyms:(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

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Chemical Property of (S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

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Technology Process of (S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

There total 7 articles about (S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3920-37-4
1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxylic acid

: 1285500-15-3
(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 17 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 5 h / 2585.81 Torr / Inert atmosphere

3.1: acetonitrile / 19 h / 100 °C / Inert atmosphere; Reflux

4.1: trichlorophosphate; N,N-diethylaniline / 18 h / 130 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium acetate / acetonitrile / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; N,N-diethylaniline; trichlorophosphate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.07.027

Reference yield:

: 59023-32-4
1,3-Dimethyl-4-aminopyrazole-5-carboxamide

: 1285500-15-3
(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 19 h / 100 °C / Inert atmosphere; Reflux

2: trichlorophosphate; N,N-diethylaniline / 18 h / 130 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium acetate / acetonitrile / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; 4: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.07.027

Reference yield:

: 109421-37-6
1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidine-5,7(4H,6H)-dione

: 1285500-15-3
(S)-1-ethyl-3-(4-(7-(3-ethylmorpholino)-1,3-dimethyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-diethylaniline / 18 h / 130 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium acetate / acetonitrile / 0.25 h / 120 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.07.027