[4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole

Base Information

• Chemical Name: [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole
• CAS No.: 202124-54-7
• Molecular Formula: C₂₆H₂₅N₅O₃S
• Molecular Weight: 487.582
• Mol file: 202124-54-7.mol

Synonyms:[4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole

Chemical Property of [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole

There total 5 articles about [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1H-benzo[d]imidazole-6-carbonitrile (6287-83-8) + N-[2-(tert-butylaminosulfonyl)(1,1'-biphenyl)-4'-yl]-2-chloroacetamide (202124-52-5) → [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole (202124-54-7) + [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-6-cyanobenzimidazole (202124-53-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm000113t

Reference yield: 37.0%

5-cyano-benzimidazole (6287-83-8) + [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methylene chloride + potassium carbonate (584-08-7) → [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole (202124-54-7) + [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-6-cyanobenzimidazole (202124-53-6)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield:

4-(2'-tert-butylaminosulfonylphenyl)aniline (193006-34-7) → [4-(2-tert-butylaminosulfonylphenyl)phenylaminocarbonyl]methyl-5-cyanobenzimidazole (202124-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / K₂CO₃ / CH₂Cl₂ / 16 h / 20 °C

2: 37 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000113t

upstream raw materials:

4-(2'-tert-butylaminosulfonylphenyl)aniline

(5-cyano-benzoimidazol-1-yl)-acetic acid methyl ester

1H-benzo[d]imidazole-6-carbonitrile

N-[2-(tert-butylaminosulfonyl)(1,1'-biphenyl)-4'-yl]-2-chloroacetamide