(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

Base Information

Chemical Name:(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate
CAS No.:1346225-82-8
Molecular Formula:C₂₅H₂₄N₂O₈S
Molecular Weight:512.54
Hs Code.:

Synonyms:(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

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Chemical Property of (R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

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Technology Process of (R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

There total 5 articles about (R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2295-31-0
thiazoline-2,4-dione

: 1346225-76-0
(R)-dimethyl 2-(3-((3-formylphenoxy)methyl)benzamido)pentanedioate

: 1346225-82-8
(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: With piperidine; acetic acid; In ethanol; at 120 ℃; for 0.666667h; Microwave irradiation; Sealed vessel;
DOI:10.1016/j.ejmech.2011.09.017

Reference yield:

: 479578-96-6
3-((3-formylphenoxy)methyl)benzoic acid

: 1346225-82-8
(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 20 °C

2.1: piperidine; acetic acid / ethanol / 0.67 h / 120 °C / Microwave irradiation; Sealed vessel

With piperidine; 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.09.017

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1346225-82-8
(R,Z)-dimethyl 2-(3-((3-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 5 h / 70 °C

2.1: sodium hydroxide / 1,4-dioxane; methanol; water / 5 h / 20 °C

2.2: pH 3

3.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: piperidine; acetic acid / ethanol / 0.67 h / 120 °C / Microwave irradiation; Sealed vessel

With piperidine; 4-methyl-morpholine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; potassium iodide; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4.1: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.09.017