(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

Base Information

Chemical Name:(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide
CAS No.:127944-54-1
Molecular Formula:C₃₈H₅₉N₇O₁₀
Molecular Weight:773.927
Hs Code.:

(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

Synonyms:(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

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Chemical Property of (S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

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Technology Process of (S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

There total 8 articles about (S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17791-52-5
(S)-2-tert-Butoxycarbonylamino-3-(3H-imidazol-4-yl)-propionic acid

: 127944-54-1
(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

2: ethanolic HCl / 1 h

3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00169a024

Reference yield:

: 119589-19-4
2-<<(benzyloxy)carbonyl>methylamino>-1-<(methoxyethoxy)methoxy>ethane

: 127944-54-1
(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 85 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, overnight

3: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

4: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00169a024

Reference yield:

: 119589-20-7
1-<(methoxyethoxy)methoxy>-2-(methylamino)ethane

: 127944-54-1
(S)-N-[(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-2-{3-[2-(2-methoxy-ethoxymethoxy)-ethyl]-3-methyl-ureido}-3-(4-methoxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, overnight

2: 100 percent / aq. LiOH / dioxane / 1 h / 0 °C

3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00169a024