2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol

Base Information

Chemical Name:2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol
CAS No.:246245-22-7
Molecular Formula:C₁₀H₁₁F₃O₂
Molecular Weight:220.191
Hs Code.:
DSSTox Substance ID:DTXSID001197482
Nikkaji Number:J1.218.544H

Synonyms:2,6-dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol;DTXSID001197482;AKOS010909949;246245-22-7;EN300-1932907;4-Hydroxy-3,5-dimethyl-alpha-(trifluoromethyl)benzenemethanol

Suppliers and Price of 2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:220.07111408
Heavy Atom Count:15
Complexity:205

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1O)C)C(C(F)(F)F)O

Technology Process of 2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol

There total 2 articles about 2,6-Dimethyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: 246245-22-7
4-(1-hydroxy-2,2,2-trifluoroethyl)-2,6-dimethyl-phenol

Guidance literature:: potassium carbonate; at 120 ℃; for 6h;
DOI:10.1246/bcsj.74.377

Reference yield: 78.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 433-27-2
ethyl trifluoroacetaldehyde hemiacetal

: 246245-22-7
4-(1-hydroxy-2,2,2-trifluoroethyl)-2,6-dimethyl-phenol

: 4,4'-(2,2,2-trifluoroethylidene)bis(2,6-dimethylphenol)

Guidance literature:: zinc(II) chloride; at 130 ℃; for 8h;
DOI:10.1246/bcsj.74.377

Reference yield: 95.0%

: 246245-22-7
4-(1-hydroxy-2,2,2-trifluoroethyl)-2,6-dimethyl-phenol

: 440659-01-8
2,6-dimethyl-4-(1-chloro-2,2,2-trifluoroethyl)phenol

Guidance literature:: With pyridine; thionyl chloride; In toluene; at 0 - 70 ℃; for 3h;
DOI:10.1055/s-2002-20458 DOI:10.1016/S0022-1139(03)00004-6