N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide

Base Information

• Chemical Name: N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide
• CAS No.: 1424357-74-3
• Molecular Formula: C₃₀H₃₀NOP
• Molecular Weight: 451.548
• Mol file: 1424357-74-3.mol

Synonyms:N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide

Chemical Property of N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide

There total 2 articles about N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(S)-4,4,5,5-tetramethyl-2-[5-phenyl-1-penten-3-yl]-1,3,2-dioxaborolane (1000376-25-9) + N-benzylidenediphenylphosphinamide (98837-46-8) → N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide (1424357-74-3)

Guidance literature:

(S)-4,4,5,5-tetramethyl-2-[5-phenyl-1-penten-3-yl]-1,3,2-dioxaborolane; N-benzylidenediphenylphosphinamide; With methanol; (S)-N-(3-(tert-butyl)-2-hydroxybenzyl)-1-(dimethylamino)-3-methyl-1-oxobutan-2-aminium; sodium t-butanolate; In toluene; at 22 ℃; for 18h; Inert atmosphere;

With sodium periodate; water; for 0.333333h; Reagent/catalyst;

Reference yield:

4,4,5,5-tetramethyl-2-(5-phenyl-1-penten-3-yl)-1,3,2-dioxaborolane + P,P-diphenyl-N-(phenylmethylene)phosphinic amide (98837-46-8,67764-52-7) → N-((1R,2R)-2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide (1424357-74-3) + N-(2-phenethyl-1-phenylbut-3-en-1-yl)-P,P-diphenylphosphinic amide

Guidance literature:

With (S)-N-(3-(tert-butyl)-2-hydroxybenzyl)-1-(dimethylamino)-3-methyl-1-oxobutan-2-aminium; sodium t-butanolate; In methanol; toluene; at 22 ℃; for 18h; Overall yield = 84 %; enantioselective reaction; Inert atmosphere;

DOI:10.1038/nature11844

upstream raw materials:

P,P-diphenyl-N-(phenylmethylene)phosphinic amide

(S)-4,4,5,5-tetramethyl-2-[5-phenyl-1-penten-3-yl]-1,3,2-dioxaborolane

N-benzylidenediphenylphosphinamide