methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

Base Information

Chemical Name:methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate
CAS No.:138252-65-0
Molecular Formula:C₂₄H₃₁NO₈S
Molecular Weight:493.578
Hs Code.:

methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

Synonyms:methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

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Chemical Property of methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

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Technology Process of methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

There total 3 articles about methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2-(tert-butyl) 3a-methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-2,3a-dicarboxylate

: 138252-65-0
methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1002/hlca.19910740720

Reference yield:

: 138252-63-8
(1R,3aS,4S,7S,7aR)-1-Hydroxymethyl-6,7-dimethyl-3-oxo-4-propionyloxymethyl-1,4,7,7a-tetrahydro-isoindole-2,3a-dicarboxylic acid 2-tert-butyl ester 3a-methyl ester

: 138252-65-0
methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 24 h / Ambient temperature

2: 96 percent / CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/hlca.19910740720

Reference yield:

: 128811-34-7
2-(tert-butyl) 3a-methyl (1R,3aS,4S,7S,7aR)-1-<<(tert-butyl)dimethylsiloxy>methyl>-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-3-oxo-4<(propanoyloxy)methyl>-1H-isoindole-2,3a-dicarboxylate

: 138252-65-0
methyl (1R,3aS,4S,7S,7aR)-2,3,3a,4,7,7a-hexahydro-6,7-dimethyl-1-<<(4-methylphenyl)sulfonyloxy>methyl>-3-oxo-4-<(propanoyloxy)methyl>-1H-isoindole-3a-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH / methanol / 9 h / Ambient temperature

2: pyridine / 24 h / Ambient temperature

3: 96 percent / CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1002/hlca.19910740720