(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

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Chemical Name:(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol
CAS No.:250355-96-5
Molecular Formula:C₄₂H₅₃NO₇Si
Molecular Weight:711.971
Hs Code.:

(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

Synonyms:(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

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Chemical Property of (2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

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Technology Process of (2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

There total 10 articles about (2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 250355-94-3
(2R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-one

: (2S,4S,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

: 250355-96-5
(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

Guidance literature:: With potassium tri-sec-butyl-borohydride; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1021/ja011604l

Reference yield:

: 6-{6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-2-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-[1,3]dioxan-4-one

: 250355-96-5
(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / tetrahydrofuran / 16 h / 65 °C

2: 89 percent / Me₂AlCl / CH₂Cl₂; hexane / 0.03 h / -78 - 20 °C

3: 89 percent / K-selectride / tetrahydrofuran / 1 h / -78 °C

With dimethylaluminum chloride; potassium tri-sec-butyl-borohydride; In tetrahydrofuran; hexane; dichloromethane; 1: Petasis-Tebbe methylenation / 2: Petasis-Ferrier rearrangement;
DOI:10.1021/ja011604l

Reference yield:

: 4-(4-{6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-methylene-[1,3]dioxan-2-yl)-2-(4-methoxy-benzyloxymethyl)-oxazole

: 250355-96-5
(2S,4R,6R)-2-{(2R,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-4-methylene-tetrahydro-pyran-2-ylmethyl}-6-[2-(4-methoxy-benzyloxymethyl)-oxazol-4-yl]-tetrahydro-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Me₂AlCl / CH₂Cl₂; hexane / 0.03 h / -78 - 20 °C

2: 89 percent / K-selectride / tetrahydrofuran / 1 h / -78 °C

With dimethylaluminum chloride; potassium tri-sec-butyl-borohydride; In tetrahydrofuran; hexane; dichloromethane; 1: Petasis-Ferrier rearrangement;
DOI:10.1021/ja011604l