1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

Base Information

Chemical Name:1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine
CAS No.:153473-69-9
Molecular Formula:C₂₀H₁₇F₃N₄O₃
Molecular Weight:418.375
Hs Code.:

Synonyms:1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

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Chemical Property of 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

Chemical Property:

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Technology Process of 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

There total 1 articles about 1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 136818-95-6
(1H-indol-2-yl)(piperazin-1-yl)methanone

: 153473-69-9
1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Ambient temperature;

Reference yield:

: 153473-69-9
1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

: 153473-70-2
[4-(2-Amino-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(1H-indol-2-yl)-methanone

Guidance literature:: With hydrogen; palladium on activated charcoal; for 18h; under 2068.6 Torr; Yield given;

Reference yield:

: 153473-69-9
1-(indolyl-2-carbonyl)-4-<2-nitro-4-(trifluoromethyl)phenyl>piperazine

: 1-(indolyl-2-carbonyl)-4-<2-<(1-methylethyl)amino>-4-(trifluoromethyl)phenyl>piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / 18 h / 2068.6 Torr

2: NaCNBH₃

With hydrogen; sodium cyanoborohydride; palladium on activated charcoal;