(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

Base Information

Chemical Name:(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]
CAS No.:401521-44-6
Molecular Formula:C₅₈H₈₆N₂O₁₆S
Molecular Weight:1099.39
Hs Code.:

Synonyms:(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

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Chemical Property of (10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

Chemical Property:

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Technology Process of (10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

There total 3 articles about (10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113777-92-7
2'-O-acetyl-4''-O-(benzyloxycarbonyl)-10,11-didehydro-6-O-methylerythromycin A

: 401521-43-5
[[3-(pyridin-4-yl)propyl]thio]acetic acid

: 401521-44-6
(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2004.04.039

Reference yield:

: 2629-72-3
4-(3-Hydroxypropyl)pyridine

: 401521-44-6
(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: NaBH₄ / ethanol / 20 °C

2.2: NaOEt / ethanol

3.1: NaOH / dioxane / 12 h / 20 °C

4.1: 413 mg / 4-dimethylaminopyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 1.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.04.039

Reference yield:

: 401521-42-4
[[3-(pyridin-4-yl)propyl]thio]acetic acid ethyl ester

: 401521-44-6
(10E)-10,11-didehydro-11-deoxy-6-O-methyl-erythromycin 2'-acetate 4''-(phenylmethyl carbonate) 12-[[[3-(pyridin-4-yl)propyl]thio]acetate]

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / dioxane / 12 h / 20 °C

2: 413 mg / 4-dimethylaminopyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2004.04.039