1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

Base Information

Chemical Name:1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline
CAS No.:1333107-41-7
Molecular Formula:C₂₃H₂₅NO₃Si
Molecular Weight:391.542
Hs Code.:

Synonyms:1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

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Chemical Property of 1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

Chemical Property:

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Technology Process of 1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

There total 4 articles about 1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1333107-18-8
4-bromo-1,7-dimethoxy-3-(4-methoxyphenyl)isoquinoline

: potassium trifluoro(2-trimethylsilylethynyl)boranuide

: 1333107-41-7
1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

Guidance literature:: With palladium diacetate; potassium carbonate; ruphos; In tetrahydrofuran; water; for 2h; Reflux; Inert atmosphere;

Reference yield:

: 181371-81-3
7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one

: 1333107-41-7
1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetic acid; ethyl acetate / 4 h / 20 °C

2: Vilsmeier reagent / 1,2-dichloro-ethane / 1 h / Reflux

3: methanol / 48 h / Reflux

4: potassium carbonate; palladium diacetate; ruphos / water; tetrahydrofuran / 2 h / Reflux; Inert atmosphere

With N-Bromosuccinimide; Vilsmeier reagent; palladium diacetate; potassium carbonate; ruphos; In tetrahydrofuran; methanol; water; acetic acid; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1333107-17-7
4-bromo-1-chloro-7-methoxy-3-(4-methoxyphenyl)isoquinoline

: 1333107-41-7
1,7-dimethoxy-3-(4-methoxyphenyl)-4-((trimethylsilyl)ethynyl)isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 48 h / Reflux

2: potassium carbonate; palladium diacetate; ruphos / water; tetrahydrofuran / 2 h / Reflux; Inert atmosphere

With palladium diacetate; potassium carbonate; ruphos; In tetrahydrofuran; methanol; water;