(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester
CAS No.:156026-86-7
Molecular Formula:C₁₆H₁₅Cl₂NO₃
Molecular Weight:340.206
Hs Code.:

Synonyms:(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

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Chemical Property of (E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

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Technology Process of (E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

There total 4 articles about (E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 156026-82-3
(E)-3-[3-(2,4-Dichloro-benzoyl)-pyrrol-1-yl]-acrylic acid ethyl ester

: 156026-86-7
(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; for 2h; Ambient temperature;

Reference yield:

: 89-75-8
2,4-dichlorobenzoyl chloride

: 156026-86-7
(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / AlCl₃ / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 96 percent / 50percent NaOH / tetrahydrofuran / 15 h / Heating

3: 95 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

4: 87 percent / NaBH₄ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 156026-78-7
(2,4-Dichloro-phenyl)-(1H-pyrrol-3-yl)-methanone

: 156026-86-7
(E)-3-{3-[(2,4-Dichloro-phenyl)-hydroxy-methyl]-pyrrol-1-yl}-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / Ambient temperature

2: 87 percent / NaBH₄ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; In tetrahydrofuran; water;