5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

Base Information

Chemical Name:5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole
CAS No.:861708-70-5
Molecular Formula:C₁₉H₁₅F₃N₂O₃S
Molecular Weight:408.401
Hs Code.:

Synonyms:5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

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Chemical Property of 5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

Chemical Property:

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Technology Process of 5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

There total 2 articles about 5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 861708-69-2
4-Chloro-5-methoxycarbonyl-2-(3-methoxyphenyl) thiazole

: 88-17-5
2-(trifluoromethyl)benzenamine

: 861708-70-5
5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 100 ℃; for 5h; Inert atmosphere;

Reference yield:

: 861708-66-9
methyl 2,4-dichlorothiazole-5-carboxylate

: 861708-70-5
5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C / Inert atmosphere

2: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 100 °C / Inert atmosphere

With sodium carbonate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; water; toluene;

Reference yield: 47.0%

: 861708-70-5
5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole

: 1026453-75-7
5-carboxyl-2-(4-methoxyphenyl)-4-(2-trifluoromethyl)aminothiazole

Guidance literature:: 5-methoxycarbonyl-2-(3-methoxyphenyl)-4-(2-trifluoromethylanilino)thiazole; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; water;