Technology Process of 4-(4-fluoro-6-hydroxyquinolin-2-yl)-3-methoxybenzoic acid
There total 5 articles about 4-(4-fluoro-6-hydroxyquinolin-2-yl)-3-methoxybenzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(dihydroxyboranyl)-3-methoxybenzoic acid; 2-chloro-4-fluoroquinolin-6-ol;
With
potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
water; N,N-dimethyl-formamide;
at 130 ℃;
for 2.5h;
Inert atmosphere;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
at 20 ℃;
pH=6;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / 6 h / Reflux
1.2: pH 7
2.1: ammonia / methanol / 16 h / 150 °C / sealed tube
3.1: pyridine; sodium nitrite; hydrogen fluoride / -10 - 0 °C
3.2: 3.5 h / 0 - 65 °C / Cooling with ice
3.3: pH 7 / Cooling with ice
4.1: boron tribromide / dichloromethane / 12 h / 20 °C
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 2.5 h / 130 °C / Inert atmosphere
5.2: 20 °C / pH 6 / Inert atmosphere
With
pyridine; hydrogen fluoride; ammonia; boron tribromide; potassium carbonate; sodium nitrite; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; sodium nitrite; hydrogen fluoride / -10 - 0 °C
1.2: 3.5 h / 0 - 65 °C / Cooling with ice
1.3: pH 7 / Cooling with ice
2.1: boron tribromide / dichloromethane / 12 h / 20 °C
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 2.5 h / 130 °C / Inert atmosphere
3.2: 20 °C / pH 6 / Inert atmosphere
With
pyridine; hydrogen fluoride; boron tribromide; potassium carbonate; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; water; N,N-dimethyl-formamide;
