3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE 2HCL

Base Information

• Chemical Name: 3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE 2HCL
• CAS No.: 24579-23-5
• Molecular Formula: C₇H₁₁N₃O
• Molecular Weight: 153.184
• Hs Code.: 2933290090
• Mol file: 24579-23-5.mol

Synonyms:2-Butanone,3-amino-4-(1H-imidazol-4-yl)- (9CI); 2-Butanone, 3-amino-4-imidazol-4-yl-(8CI); 4-(4-Imidazolyl)-3-amino-2-butanone; 4-Imidazolyl-3-amino-2-butanone;McN-A 1293

Chemical Property of 3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE 2HCL

Chemical Property:

• Vapor Pressure: 9.1E-06mmHg at 25°C
• Boiling Point: 373.2°Cat760mmHg
• Flash Point: 179.5°C
• PSA: 71.77000
• Density: 1.196g/cm³
• LogP: 2.17280

Purity/Quality:

97% ^*data from raw suppliers

3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE 2HCL

There total 5 articles about 3-AMINO-4-(1H-IMIDAZOL-4-YL)-BUTAN-2-ONE 2HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-acetylamino-4-(1(3)H-imidazol-4-yl)-butan-2-one (70205-45-7) → 3-amino-4-(1(3)H-imidazol-4-yl)-butan-2-one (24579-23-5)

Guidance literature:

With hydrogenchloride; water; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jnatprod.7b00317

Reference yield:

acetic anhydride (108-24-7) + L-histidine (71-00-1) → 3-amino-4-(1(3)H-imidazol-4-yl)-butan-2-one (24579-23-5)

Guidance literature:

With pyridine; Eindampfen des Reaktionsprodukts mit verd.Salzsaeure;

Reference yield:

L-histidine (71-00-1) → 3-amino-4-(1(3)H-imidazol-4-yl)-butan-2-one (24579-23-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / Inert atmosphere; Cooling with ice; Reflux

2: hydrogenchloride; water / 12 h / Inert atmosphere; Reflux

With pyridine; hydrogenchloride; water;

DOI:10.1021/acs.jnatprod.7b00317

upstream raw materials:

acetic anhydride

L-histidine

3-acetylamino-4-(1⁽³⁾H-imidazol-4-yl)-butan-2-one

Downstream raw materials:

N-<1-(1H-Imidazol-4-ylmethyl)-2-oxopropyl>-2-(phenylmethoxy)acetamide

Refernces

• 1、 Lin, Zhenjian,Smith, Misty D.,Concepcion, Gisela P.,Haygood, Margo G.,Olivera, Baldomero M.,Light, Alan,Schmidt, Eric W.. "Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products". . p. 2360 - 2370. Retrieved 2017/09/01.