3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

Base Information

Chemical Name:3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate
CAS No.:1291106-98-3
Molecular Formula:C₂₂H₂₁ClF₃N₃O₅S
Molecular Weight:531.94
Hs Code.:

Synonyms:3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

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Chemical Property of 3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

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Technology Process of 3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

There total 5 articles about 3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1291106-97-2
C₂₂H₂₁ClF₃N₃O₄S

: 1291106-98-3
3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

Guidance literature:: With dihydrogen peroxide; acetic acid; In water; at 20 ℃; for 3h;

Reference yield:

: 100777-49-9
2-((3-methoxy-4-nitrophenyl)thio)ethan-1-ol

: 1291106-98-3
3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 15 - 20 °C

2: caesium carbonate / acetonitrile / 60 °C

3: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 16 h / 20 °C

4: hydrogen bromide / 8 h / 150 °C

5: triethylamine / N,N-dimethyl-formamide / 20 °C

6: tetrahydrofuran / 3 h / 20 °C

7: dihydrogen peroxide; acetic acid / water / 3 h / 20 °C

With hydrogen bromide; hydrogen; dihydrogen peroxide; caesium carbonate; acetic acid; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 1291106-98-3
3-chloro-5-trifluoromethylbenzyl 4-[2-(2-oxo-2,3-dihydrobenzooxazole-6(R)-sulfinyl)ethyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / acetonitrile / Reflux

2: triethylamine / dichloromethane / 15 - 20 °C

3: caesium carbonate / acetonitrile / 60 °C

4: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 16 h / 20 °C

5: hydrogen bromide / 8 h / 150 °C

6: triethylamine / N,N-dimethyl-formamide / 20 °C

7: tetrahydrofuran / 3 h / 20 °C

8: dihydrogen peroxide; acetic acid / water / 3 h / 20 °C

With hydrogen bromide; hydrogen; dihydrogen peroxide; potassium carbonate; caesium carbonate; acetic acid; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;