(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

Base Information

Chemical Name:(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate
CAS No.:1443526-59-7
Molecular Formula:C₂₁H₂₃BrO₆S
Molecular Weight:483.38
Hs Code.:

Synonyms:(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

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Chemical Property of (E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

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Technology Process of (E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

There total 6 articles about (E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1443526-58-6
(E)-ethyl 4-(6-bromo-3-hydroxy-2-methoxyphenyl)-2-methylbut-2-enoate

: 98-59-9
p-toluenesulfonyl chloride

: 1443526-59-7
(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2013.05.007

Reference yield:

: 214123-07-6
6-bromo-3-hydroxy-2-methoxybenzaldehyde

: 1443526-59-7
(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

3: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere; Reflux

4: dichloromethane / 1 h / 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 2: |Wittig Olefination;
DOI:10.1016/j.tet.2013.05.007

Reference yield:

: C₁₄H₂₁BrO₃Si

: 1443526-59-7
(E)-ethyl 4-(6-bromo-2-methoxy-3-(tosyloxy)phenyl)-2-methylbut-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere; Reflux

3: dichloromethane / 1 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane; water; 1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.05.007