(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Chemical Name:(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide
CAS No.:1223498-38-1
Molecular Formula:C₁₈H₂₄BrN₅O₂S
Molecular Weight:454.391
Hs Code.:

Synonyms:(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Chemical Property of (R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

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Technology Process of (R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

There total 3 articles about (R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1223498-64-3
C₂₁H₂₈BrN₅O₄S

: 1223498-38-1
(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: With sodium ethanolate; In ethanol; at 60 ℃; for 18h;

Reference yield: 77.0%

: (R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(ethoxycarbonyl)sulfoximide

: 1223498-38-1
(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: (R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}pyrimidin-2-yl)amino]phenyl}-S-cyclopropyl-N-(ethoxycarbonyl)sulfoximide; With sodium ethanolate; In ethanol; at 60 ℃; for 18h;

With water; sodium chloride; In ethanol;
DOI:10.1002/cmdc.201300096

Reference yield:

: 851008-30-5
(R)-3-[(5-bromo-2-chloropyrimidin-4-yl)amino]-2-methylbutan-2-ol

: (R)-S-(4-aminophenyl)-N-(ethoxycarbonyl)-S-cyclopropylsulfoximide

: 1223498-38-1
(R)-S-{4-[(5-bromo-4-{[(R)-2-hydroxy-1,2-dimethylpropyl]amino}-pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / butan-1-ol; 1,4-dioxane; methanol / 72 h / 60 °C

2: sodium ethanolate / ethanol / 18 h / 60 °C

With hydrogenchloride; sodium ethanolate; In 1,4-dioxane; methanol; ethanol; butan-1-ol;