2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol

Base Information

• Chemical Name: 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol
• CAS No.: 480466-36-2
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 218.296
• Mol file: 480466-36-2.mol

Synonyms:2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol

Chemical Property of 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol

There total 4 articles about 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-acetoxy-2-methyl-2-[3-(4-chlorobutyryl)phenyl]propane (480466-35-1) + 2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methyl propanyl acetate (169032-11-5) → 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol (169280-26-6) + 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol (480466-36-2)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 2h;

Reference yield:

neophyl chloride (515-40-2) → 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol (169280-26-6) + 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol (480466-36-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-methyl-pyrrolidin-2-one / 160 - 165 °C

2.1: aluminum (III) chloride / dichloromethane / 0 - 5 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: sodium hydroxide; methanol / 2 h / 20 °C

With methanol; aluminum (III) chloride; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; dichloromethane;

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-(4-(1-Oxo-1-cyclopropanyl)-phenyl)-2-methylpropanol (169280-26-6) + 2-(3-cyclopropylcarbonyl)phenyl-2-methyl propanol (480466-36-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 160 - 165 °C

3.1: aluminum (III) chloride / dichloromethane / 0 - 5 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

4.1: sodium hydroxide; methanol / 2 h / 20 °C

With methanol; aluminum (III) chloride; sulfuric acid; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; dichloromethane;

upstream raw materials:

benzene

1-acetoxy-2-methyl-2-[3-(4-chlorobutyryl)phenyl]propane

2-(4-(4-Chloro-1-oxo-butyl))-phenyl-2-methyl propanyl acetate

(2-acetoxy-1,1-dimethylethyl)benzene

Refernces