3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile

Base Information

• Chemical Name: 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile
• CAS No.: 207725-74-4
• Molecular Formula: C₁₄H₂₅NOSi
• Molecular Weight: 251.444

Synonyms:3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile

Chemical Property of 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile

Chemical Property:

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Technology Process of 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile

There total 1 articles about 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

(R)-3-(1-methyl-2-oxocyclohexyl)propanenitrile (163877-34-7) + chloro(trimethylsilyl)methyl lithium (63830-85-3) → 3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile (207725-74-4) + 3-[(R)-2-(Chloro-trimethylsilanyl-methyl)-2-hydroxy-1-methyl-cyclohexyl]-propionitrile

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1016/S0040-4039(98)00390-6

Reference yield: 90.0%

3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile (207725-74-4) → 3-((R)-2-Formyl-1-methyl-cyclohexyl)-propionitrile

Guidance literature:

With trifluoroacetic acid; In methanol; at 20 ℃; for 12h;

DOI:10.1016/0957-4166(94)80071-5

Reference yield: 76.0%

3-((R)-4-Methyl-2-trimethylsilanyl-1-oxa-spiro[2.5]oct-4-yl)-propionitrile (207725-74-4) → 3-[(R)-2-(Bromo-trimethylsilanyl-methyl)-2-hydroxy-1-methyl-cyclohexyl]-propionitrile (207725-80-2)

Guidance literature:

With hydrogen bromide; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(98)00390-6

upstream raw materials:

(R)-3-(1-methyl-2-oxocyclohexyl)propanenitrile

chloro(trimethylsilyl)methyl lithium

Downstream raw materials:

3-[(R)-2-Hydroxy-2-(hydroxy-trimethylsilanyl-methyl)-1-methyl-cyclohexyl]-propionitrile

3-[(R)-2-(Bromo-trimethylsilanyl-methyl)-2-hydroxy-1-methyl-cyclohexyl]-propionitrile

3-{(R)-1-Methyl-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-propionitrile

4-{(R)-1-Methyl-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-butan-2-one

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