Technology Process of Boc-Aib-Orn(δ-Z)-Leu-D-Phe-Pro-OEt
There total 5 articles about Boc-Aib-Orn(δ-Z)-Leu-D-Phe-Pro-OEt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; triethylamine; isopentyl nitrite;
In
1,4-dioxane; dichloromethane;
at 0 ℃;
for 120h;
DOI:10.1246/bcsj.60.1391
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / 2 M NaOH, Et3N / dioxane / 40 h / Ambient temperature
2: 88 percent / NMM, HOBt, EDC*HCl / dimethylformamide / 72 h / Ambient temperature
3: 92 percent / hydrazine hydrate / methanol / 16 h / 28 °C
4: 73 percent / HCl, isopentyl nitrite, Et3N / CH2Cl2; dioxane / 120 h / 0 °C
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopentyl nitrite;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.1391
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / NMM, HOBt, EDC*HCl / dimethylformamide / 72 h / Ambient temperature
2: 92 percent / hydrazine hydrate / methanol / 16 h / 28 °C
3: 73 percent / HCl, isopentyl nitrite, Et3N / CH2Cl2; dioxane / 120 h / 0 °C
With
4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isopentyl nitrite;
In
1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.60.1391
