methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

Base Information

Chemical Name:methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate
CAS No.:1012059-90-3
Molecular Formula:C₂₅H₃₁N₃O₅S₂
Molecular Weight:517.67
Hs Code.:

Synonyms:methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

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Chemical Property of methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

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Technology Process of methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

There total 7 articles about methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1012059-90-3
methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

Guidance literature:

Reference yield: 12.0%

: 1012059-89-0
2-(4-(5-methoxy-5-oxopentyloxy)phenyl)acetic acid

: 224436-97-9
2-amino-5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-thiazole

: 1012059-90-3
methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

Reference yield:

: 76779-98-1
1-azido-3,3-dimethyl-2-butanone

: 1012059-90-3
methyl-5-(4-(2-(5-((5-tert-butyloxazol-2-yl)methylthio)-thiazol-2-ylamino)-2-oxoethyl)phenoxy)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol

2.1: triethylamine / dichloromethane / 1.25 h / -10 - -5 °C

3.1: trichlorophosphate / 1 h / 105 °C

4.1: ethanol; sodium tetrahydroborate / acetone / 1 h / 20 °C

4.2: 1 h / Reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 4 h / 40 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;