1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide

Base Information

• Chemical Name: 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide
• CAS No.: 1265501-02-7
• Molecular Formula: C₂₄H₁₇F₆N₇O₅
• Molecular Weight: 597.433
• Mol file: 1265501-02-7.mol

Synonyms:1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide

Chemical Property of 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide

There total 6 articles about 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-nitroveratraldehyde (55149-84-3) + 1-(2,8-bistrifluoromethylquinolin-4-yl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1265500-84-2) → 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1265501-02-7)

Guidance literature:

In methanol; acetic acid; for 1h; Reflux;

DOI:10.1007/s12272-010-1204-3

Reference yield:

C16H10F6N4O2 → 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1265501-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 8 h / 80 °C

2: methanol; acetic acid / 1 h / Reflux

With hydrazine hydrate; In methanol; ethanol; acetic acid;

DOI:10.1007/s12272-010-1204-3

Reference yield:

4-azido-2,8-bis(trifluoromethyl)quinoline (1258291-33-6) → 1-(2,8-bistrifluoromethylquinolin-4-yl)-N'-(2-nitro-3,4-dimethoxybenzylidene)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide (1265501-02-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium methylate / methanol / 0 °C / Inert atmosphere

2: thionyl chloride; N,N-dimethyl-formamide / chloroform / 0 - 5 °C / Reflux

4: hydrazine hydrate / ethanol / 8 h / 80 °C

5: methanol; acetic acid / 1 h / Reflux

With thionyl chloride; sodium methylate; hydrazine hydrate; N,N-dimethyl-formamide; In methanol; ethanol; chloroform; acetic acid;

DOI:10.1007/s12272-010-1204-3

upstream raw materials:

(2,8-bis-trifluoromethyl)-4-bromoquinoline

2-nitroveratraldehyde

1-(2,8-bistrifluoromethylquinolin-4-yl)-5-methyl-1H-1,2,3-triazole-4-carbohydrazide

4-azido-2,8-bis(trifluoromethyl)quinoline